Specify HTTP methods using the methods parameter in the route decorator:

@app.route('/api/users', methods=['GET', 'POST'])
def handle_users():
    if request.method == 'POST':
        return create_user()
    return get_users()

@app.route('/api/users/<int:user_id>', methods=['PUT', 'DELETE'])
def handle_user(user_id):
    if request.method == 'PUT':
        return update_user(user_id)
    elif request.method == 'DELETE':
        return delete_user(user_id)