PowerShell ISE (Integrated Scripting Environment): A graphical interface for writing, testing, and debugging PowerShell scripts. It's Windows-only and comes with Windows PowerShell.

PowerShell Core: The cross-platform version built on .NET Core, designed to run on Windows, Linux, and macOS.

Key differences:

• Platform support: ISE is Windows-only; Core is cross-platform
• Base framework: ISE uses .NET Framework; Core uses .NET Core
• Performance: Core is generally faster and more lightweight
• Module compatibility: Some Windows PowerShell modules aren't compatible with Core
• Development: Core is actively developed; ISE development has stopped